Recurrent Glioblastoma Brain Tumors:
Novel Superselective Intraaterial Cerebral Approach Using Avastin Yields Successful Results
Two neurosurgeons in the Department of Neurosurgery, Dr. John A. Boockvar and Dr. Howard A. Riina, are pioneering an exciting new approach for the treatment of recurrent malignant brain tumors. As reported in the New York Times November 17th, their novel approach to treating these resistant brain tumors is yielding successful results. Follow up MRI imaging on the treated patients has shown that their tumors have shown a dramatic response to the treatment. Glioblastoma Multiforme (GBM) is an aggressive brain tumor and these tumors invariably recur despite the best efforts of standard treatment, which combines removal of the tumor with radiation and chemotherapy.
With standard treatment, the drugs enter the patient’s body via the veins or IV, resulting in toxicity to the patient. Drs. Boockvar and Riina decided to devise a new approach that would provide a much more efficient delivery system that would target the tumor directly via the arteries deep in the brain. Until now the BBB, or Blood Brain Barrier, has been an obstacle to the effective direct delivery of chemotherapy treatment for brain tumors. Using a super-selective microcatheter, a medication is used to first disrupt the blood brain barrier then directly target the brain tumor with the drug Avastin. This groundbreaking development is sparing patients from adverse drug toxicity and may usher in a revival of Interventional Neuro-oncology.
The first phase of their clinical trial is underway and their first case will be published this month in the Journal of Experimental Therapeutics and Oncology.
Click Here for New York Times Article.
Click here to watch the CNBC interview
For more information on
this trial please visit Clinical Trials.Gov
http://clinicaltrials.gov/ct2/show/NCT00968240?term=boockvar=1
or call 212-746-1996 or email jab2029@med.cornell.edu or
shb9024@nyp.org.
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